• Karl-Dimiter Bissig

    Chen Family Associate Professor, Department of Pediatrics

    Email: karl-dimiter.bissig@duke.edu

    MD, School of Medicine, University of Bern, 01/1996

    PhD, School of Medicine, University of Bern, 01/2000

    Clinical Fellowship, Internal Medicine and Gastroenterology, University Hospital Bern, 01/2005

    Postdoctoral Fellowship, Salk Institute for Biological Studies, 02/2011

    About Me
    My fascination with the liver first began during my medical training, influenced by interdisciplinary hepatology research going on at University of Bern. After completing my medical education, I pursued a PhD in molecular biology and biochemistry working on Wilson's Disease and moved to the US as a postdoc in cancer biology and gene therapy after completing my PhD and internal medicine fellowship. During my education, I have kept the vision of doing interdisciplinary research to improve human health in mind. It is something I have carried over through my time at the Salk Institute and Baylor College of Medicine, where I started my own lab. I am excited to continue pursuing that vision at Duke University and expand therapeutic alternatives to children with inborn error of metabolism.
    Outside the lab, I am interested in exploring other countries and cultures, kite surfing and snowboarding or just having a good time with my family and friends
  • Mercedes Barzi


    Email: mercedes.barzi@duke.edu

    B.S. and M.S. in Biology, Autonomous University of BarcelonaPh.D.

    Ph.D. in Molecular Biology, University of Barcelona

    About Me
    In 2011, I joined Dr. Karl-Dimiter Bissig’s laboratory at Baylor College of Medicine in Houston (Texas) where I developed a novel human chimeric mouse model to study human drug metabolism. My current research at Duke is focused on treating metabolic disorders using innovative therapies such as CRISPR/Cas9 engineering tools and AAV delivery methods. I am also evaluating the safeness and long-term effects of these treatments.
    In my free time, I enjoy practicing yoga, dancing Cuban salsa and walking around the beautiful forests of North Carolina.
  • Beatrice Bissig-Choisat

    Assistant Professor

    Email: beatrice.bissigchoisat@duke.edu
    D.V.M, University of Bern, Switzerland
    About Me
    I am a veterinarian-scientist with expertise in human liver chimeric mice. I developed different model for metabolic liver disease. My research interest focus is in liver metabolism, particularly NAFLD.
    Outside of research, I am an avid reader and love to hike, swim and kitesurf. I enjoy cooking and trying new recipes for the family and friends.
  • Tong Chen

    Ph.D. Candidate

    Molecular Genetics and Microbiology, Duke University
    Email: tong.chen8@duke.edu
    M.D. Wenzhou Medical University, China
    M.S. Medicine, Wenzhou Medical University, China
    About Me
    I am interested in genome engineering in the liver and developing novel therapeutic strategies to cure chronic HBV infection. In my spare time I like to bake, draw, and take photos.
  • Sabrina Collias

    Lab Manager

    Email: sabrina.collias@duke.edu
    B.S. Psychology, University of North Carolina at Chapel Hill
    About Me
    I am a Research Technician in the Bissig Lab. I am experienced with mouse colony management, sample collection, processing, and analysis. I graduated from The University of North Carolina at Chapel Hill in 2019 with a Bachelor of Science in Psychology. Outside the lab, you can find me listening to audible books and painting.
  • Madeline Hemmingsen

    Ph.D. Candidate

    Genetics and Genomics, Duke University
    Email: madeline.hemmingsen@duke.edu
    B.S. Genetics, Clemson University
    About Me
    I am a Ph.D. student working on treating inborn errors of metabolism in the liver using novel murine models, CRISPR/Cas9 and AAV technology. I was drawn to the Bissig lab by the interdisciplinary and translational approach our lab takes, in addition to the cutting edge research. When I'm not in the lab, you can find me horseback riding, working on DIY projects, learning Russian, gaming, or hanging out with my two cats.