Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. These humanized mouse models will help to advance and improve experimental therapies for liver disease.
Our most recent work, published in Science Translational Medicine, identified a new cause for Glutaric Aciduria 1, an inherited metabolic disease common among the Lumbee population and other Native American heritages. See the press release here.
Our newest publication, Rescue of glutaric aciduria type I in mice by liver-directed therapies, has been published!
April 19, 2023
Madeline presented a poster at the 2022 European Society of Gene and Cell Therapy Congress in Edinburgh"
October 11-14, 2022
Bea and Mercedes were awarded the Young Investigator Award at the 6th International Workshop on Humanized Mice for their talk "A novel human liver chimeric mouse model lacking the murine AAVR gene for validation of AAV gene therapy vectors"
October 13th, 2022
Several lab members attended and presented at SSIEM Annual Symposium in Freiburg, Germany"
Aug 30-Sept 2, 2022
Dimi organized and spoke at the EMBO Practical Course "Humanized mice, personalized therapies and big data in Heidelberg
June 12-17, 2022
Tong and Mercedes presented at the 25th Annual ASGCT conference in Washington DC, both receiving travel awards
May 16-19, 2022